ALIA

ALLYLESTRENOL

Allylestrenol is indicated in Intra Uterine Growth Retardation (IUGR), Threatened abortion, Habitual abortion, Threatened premature delivery

Female Sex hormones

Allylestrenol is a synthetic progesterone derivative that is used to treat threatened pregnancies. It can stop occurring premature labor and can help women give birth to a healthy newborn. It stimulates the secretory phase in myometrium, creates conditions for development of fertilized ovum. It has a tocolytic effect; reduces sensitivity of myometrium to oxytocin. It stimulates the development of acinus of mammary glands, secretory activity of trophoblasts, and development of aldosterone by adrenal glands. Allylestrenol also has a selection of 8-adrenergic effect. In this way, it stimulates the synthesis of the body's placental progesterone, therefore increasing the secretion of placental hormones.

Threatened Abortion: 5 mg three times daily for 5-7 days. If necessary, the treatment period may be extended. After disappearance of the symptoms the dosage should be gradually reduced unless symptoms return. Habitual abortion: 5-10 mg daily as soon as pregnancy has been diagnosed. The administration should be continued until at least one month after the end of the critical period. Threatened premature labor: The dosage must be determined individually. High dosages (up to 40 mg daily) have been used.

Hypersensitivity; thrombophlebitis; undiagnosed vaginal bleeding, incomplete abortion, hormone-dependent carcinoma, cerebral apoplexy, as a diagnostic test for pregnancy; severe hepatic impairment.

Treatment with Allylestrenol (especially a long term treatment) is known to cause some gastrointestinal complaints such as vomiting, nausea, and sometimes epigastric discomfort.

Allylestrenol is specifically designed to be taken during pregnancy. It should be discontinued after delivery as it may affect a nursing infant to a small but noticeable degree.

Symptoms of overdose may include unusual drowsiness; rapid pulse; fainting; unusual muscle movement or rigidity of the face, neck, or limbs; seizures; and loss of consciousness.

Patients with the following conditions should be cautious: Heart disease, congestive heart failure, sick sinus syndrome, coronary artery disease, seizures, epilepsy, renal dysfunction, migraine headaches, or breathing diseases including asthma, emphysema, chronic bronchitis, or COPD, breast-feeding.

Store in a cool & dry place protected from light & moisture. Keep out of reach of the children.