ASIDOX

DOXYCYCLINE HYDROCHLORIDE

Doxycycline Hydrochloride is indicated in the following infections caused by susceptible microorganisms : Pneumonia and other respiratory tract infections caused by Klebsiella, Pneumococci and Mycoplasma pneumoniae Gastrointestinal infections Genitourinary tract infections Soft tissue infections Ophthalmic infections (trachoma) caused by Chlamydia trachomatis Acne Prophylaxis of Plasmodium falciparum malaria Miscellaneous group of infections : Prostatitis, Psittacosis, Trigonitis, Louse borne typhus, Plague etc.

Tetracycline group of drugs

Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It has bacteriostatic activity against a broad range of gm+ve and gm-ve bacteria.

Usual dose: 200 mg on first day, then 100 mg daily for 7-10 days. Severe infections (including refractory urinary tract infections): 200 mg daily for 10 days. Acne: 100 mg daily. Uncomplicated genital chlamydia, non-gonococcal urethritis: 100 mg twice daily for 7-21 days (14-21 days in pelvic inflammatory disease).

Should not be taken with antacids, milk, other alkalis e.g. calcium, magnesium and iron, penicillin, anticoagulants, anti-diabetic agents, anticonvulsants and enzyme inducing drugs

Doxycycline Hydrochloride is contraindicated in pregnancy and lacatation, children under 12 years of age and in patients with known hypersensitivity to any of the Tetracyclines.

Since Doxycycline Hydrochloride is virtually completely absorbed, side effects of the lower bowel particularly diarrhoea have been infrequent. Gastrointestinal effects e.g., anorexia, nausea, diarrhoea, vomiting, glossitis, dysphagia, enterocolitis and anogenital inflammatory lesions have been reported occasionally. Hypersensitivity reactions e.g., urticaria, angioneurotic oedema, anaphylactic purpura, pericarditis and exacerbation of systemic lupus erythematosus may occur. Haemolytic anaemia, thrombocytopenia, neutropenia and eosinophilia have also been reported. On rare occasions, anaphylaxis may occur.

Pregnancy: Doxycycline should be avoided in pregnant women, because of the risk of both staining and effect on bone growth in the foetus. Lactation: Doxycyclines enter breast milk, and mothers taking these drugs should not breastfeed their child.

During development of teeth (last trimester of pregnency, upto 12 yrs of age) the use of tetracyclines may lead to discoloration of teeth. So tetracyclines should not be administered during these periods

It should be stored in a dry place at room temperature.