BETAMESAL

BETAMETHASONE + SALICYLIC ACID

Betamethasone & Salicylic Acid Scalp lotion or ointment is indicated for the relief of inflammatory manifestations of psoriasis and seborrhea of the scalp. This scalp lotion or ointment is also indicated for the relief of inflammatory manifestations of non-scalp lesions of psoriasis and other corticosteroid responsive dermatoses.

Topical anti-inflammatory preparations

Betamethasone is a glucocorticoid receptor agonist. This leads to changes in genetic expression once this complex binds to the GRE. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Betamethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin. Salicylic acid directly and irreversibly inhibits the activity of both types of cyclo-oxygenases (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Salicylate may competitively inhibit prostaglandin formation. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms. Salicylic acid is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. It works by causing the cells of the epidermis to slough off more readily, preventing pores from clogging up, and allowing room for new cell growth. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff.

Apply few drops of Betamethasone & Salicylic Acid Scalp lotion or ointment to the affected area and massage gently and thoroughly onto the scalp or skin. The usual frequency of application is twice daily, in the morning and at night.

Betamethasone & Salicylic Acid Scalp lotion or ointment is contraindicated in those patients with a history of sensitivity reactions to any of its components.

Side effects that have been reported with the application of topical corticosteroids include burning, itching, irritation, dryness, folliculitis, hypertrichosis, hypopigmentation, perioral dermatitis, and allergic contact dermatitis. Salicylic Acid preparations may cause dermatitis.

The safety of this medicine during pregnancy and breastfeeding has not been established. However, topical steroid should not be used extensively in pregnancy i.e. in large amount or for prolonged period.

Overdose of topical corticosteroids can suppress pituitary-adrenal functions resulting in secondary adrenal insufficiency and produce manifestations of hypercorticism, including Cushing's disease. With topical preparations containing Salicylic Acid, overdose of it may result in symptoms of salicyclism.

If irritation or sensitization develops with the use of Betamesal Scalp lotion or ointment, treatment should be discontinued. Systemic absorption of topical corticosteroids or Salicylic Acid may be increased if extensive body surface areas are treated. Application of Salicylic Acid to open wounds or damaged skin should be avoided.