CAFTADIN

ALCAFTADINE

Alcaftadine eye drops indicated for the treatment of signs and symptoms (itchy, watery, red and swollen eyes and/or eyelids) of allergic conjunctivitis including vernal keratoconjunctivitis, vernal keratitis, blepharitis, blepharoconjunctivitis and giant papillary conjunctivitis.

Ophthalmic Anti-allergic preparations

Alcaftadine is a potent histamine H1, H2 & H4 receptor antagonist with anti-inflammatory properties. The activation of H1 receptor causes itching & H4 receptor causes itching & inflammation. Histamine binding with H1 & H2 receptor causes redness and swelling. Alcaftadine also inhibit the release of histamine from mast cell through limit the entry of Ca++ across the membrane as a result prevent degranulation. Alcaftadine also stabilize tight junction protein (zonula occludin) of conjuctival epithelium that normally becomes disorganized following allergen exposure so that decreased chemotaxis and inhibition of eosinophil activation has also been demonstrated.

The recommended dose of Alcaftadine eye drops is 1 drop in the affected eye(s) once a day.

It is contraindicated in persons with a known hypersensitivity to any component of this product.

Common side effects of Alcaftadine include mild and temporary burning/ stinging/ irritation of the eyes, eye redness or itching, runny or stuffy nose, sore throat, flu symptoms or headache.

Pregnancy Category B. Reproduction studies performed in rats and rabbits revealed no evidence of impaired female reproduction or harm to the fetus due to alcaftadine.There are however, this drug should be used during pregnancy only if clearly needed. Nursing Mothers: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when alcaftadine eye drops is administered to a nursing woman.

Ocular Adverse Reactions: The most frequent ocular adverse reactions, occurring in <4% of alcaftadine eye drops treated eyes were eye irritation, burning and/or stinging upon instillation, eye redness and eye pruritus. Non-ocular Adverse Reactions: The most frequent non-ocular adverse reactions, occurring in <3% of subjects with alcaftadine eye drops treated eyes, were nasopharyngitis, headache and influenza. Some of these events were similar to the underlying disease being studied.

Contamination of Tip and Solution To minimize contaminating the dropper tip and solution, care should be taken not to touch the eyelids or surrounding areas with the dropper tip of the bottle. Keep bottle tightly closed when not in use. Contact Lens Use Remove contact lenses prior to instillation of Alcaftadine. Lenses may be reinserted after 10 minutes following administration of Alcaftadine.

Should be stored at room temperature. Protect from light. Close the bottle immediately after use. Do not use for longer than one month after opening the bottle.