SQUARE PHARMACEUTICALS LTD.
FUSIDIC ACID + HYDROCORTISONE
This is indicated in eczema and dermatitis with secondary infections including atopic dermatitis, allergic and seborrhoeic dermatitis and primary irritant dermatitis.
Hydrocortisone & Combined preparationsa
Fusidic Acid BP 2% & Hydrocortisone Acetate BP 1% combination cream contains the potent topical antibacterial action of Fusidic Acid with the anti-infammatory & anti-pruritic efects of Hydrocortisone Acetate. When applied topically, Fusidic Acid is efective against Staphylococci, Streptococci, Corynebacteria, Neisseria and certain Clostridia & Bacteroides. Fusidic Acid is an antimicrobial agent that acts as an inhibitor of protein synthesis in the microorganism. It interferes with translocation step by stabilizing the ribosome-guanosine diphosphate elongation factor G-complex. This prevents binding of aminoacyl t-RNA to the ribosome and thereafter stops transfer of additional amino acids to the growing polypeptide. In humans, Hydrocortisone is the principal naturally occurring glucocorticosteroid. In pharmaceutical dosage, its main action is to reduce the response of the skin to injury (i.e. anti-infammatory). It also has immunosuppressant & anti-mitotic actions.
Adults: 3 times daily and gently massaged onto the affected areas for 2 weeks. A shorter course should be considered if symptoms improve. Children: It is not recommended in children under 3 years of age.
Fusidic Acid may inhibit the metabolism of drugs which undergo extensive bio-transformation in the liver, but no evidence for this is available. Food may delay absorption of Fusidic Acid. No hazardous drug interactions are reported with topical hydrocortisone.
Contraindicated in- Known hypersensitivity to any of the components. Severe hepatic failure. lnfection-bacterial, viral, fungal, skin infection. Ulcers (delayed wound healing). Infants under 1 year.
Fusidic Acid has been reported to cause mild irritation at the application site, but did not usually require discontinuation of therapy. Reports of hypersensitivity reactions have been rare. Adverse efects are generally local and include: dryness, itching, burning, local irritation, striae, skin atrophy, atrophy of subcutaneous tissues, telangiectasia, hypertrichosis, change in pigmentation and secondary infection. If applied to the face, acne rosacea or perioral dermatitis can occur.
Fusidic Acid & Hydrocortisone should not be used in pregnancy. Both of them have been detected in the breast milk, so nursing mothers are advised not to use the drug.
Long term continuous therapy should be avoided, particularly in the face, on flexures, and intertrigenous areas, and in infants and children
Store below 308 C, away from light and moisture. Keep out of the reach of children.