Oushod Sheba

Oushod Sheba

All category



300 MG


Generic Information

Generic name



Gabapentin is indicated for- Epilepsy Neuropathic pain (e.g. postherpetic neuralgia) and other pain conditions Bipolar disorder Headache syndrome Spasticity in multiple sclerosis and spinal cord diseases Others indication are: Alcohol withdrawal Schizoaffective disorder Post-traumatic stress disorder Agitation and behavioural disturbances associated with dementia Lesch-Nyhan syndrome Essential tremor Restless legs syndrome Brachioradial pruritus Hemichorea/hemiballismus Hot Flashes

Therapeutic Class

Adjunct anti-epileptic drugsa


Gabapentin is an anti-convulsant. It is a structural analog of gamma-amino-butyric-acid (GABA). All pharmacological actions following administration of Gabapentin are due to the activity of parent compound. Gabapentin binds with the alpha-2-delta subunit of voltage gated L-type Calcium channel, and inhibits branched chain amino acid transferase & probably inhibits neurotransmitter release of excitatory amino acid.

Dosage & Administration

Neuropathic pain: 300 mg on day-1, then 300 mg twice on day-2, then 300 mg thrice on day-3, then increase the dose according to response in steps of 300 mg daily to maximum 1800 mg daily in three divided doses. Partial seizure/epilepsy: 300 mg on day-1, then 300 mg twice on day-2, then 300 mg thrice on day-3, then increase the dose according to response in steps of 300 mg daily to maximum 2400 mg daily in three divided doses. In case of children: For 3-12 years: 10 to 15 mg/kg, Incase of titration 25-35 mg/kg daily in 3 divided doses. Maintenance dose is 900 mg daily (body weight 26-36 Kg) or 1.2 gm daily (body weight 37-50 Kg). Gabapentin can be taken orally with or without food.


Antacids may reduce the bioavailability of Gabapentin by up to 20%. Cimetidine may alter its reanal excretion. Gabapentin does not interact with other anti-epileptic drug or with oral contraceptive preparations.


Gabapentin is contraindicated in patients who have known hypersensitivity to the drug.

Side Effects

Generally Gabapentin is well tolerated but a few side effects like fatigue, dizziness , ataxia, weight gain, peripheral edema, dry mouth and somnolence, may occur. Rarely it may cause fulminate hepatic failure, or aplasticanemia.

Pregnancy & Lactation

Pregnancy: Gabapentin is a pregnancy category C drug; it should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Lactation: Gabapentin may be secreted through the breast milk like many other drugs , so it should be used in women who are nursing, only if the benefits clearly outweigh the risks.

Overdose Effects

Precaution & Warnings

Patients should be instructed to take Gabapentin only as prescribed. While using Gabapentin patients should be instructed either not to drive a car or to operate other complex machinery until they have gained sufficient experiences about Gabapentin whether or not it affects their mental and/or motor performance adversely.

Storage Conditions

Tablets should be stored below 258 C and protected from light & moisture